This deliverable provides details for the use cases and the specific scenarios that will run throughout the lifespan of the MaTHiSiS project. This document analyses and reports on the results of semi-structured interviews with representative stakeholders (teachers and learners) from the five Use Cases specified in the MaTHiSiS project proposal (Autistic Spectrum, Profound and Multiple Learning Disabilities, Mainstream Education, Industrial Training and Career Guidance Distance Learning).